NR 508 Week 7 Discussions 1 (Part Two) Recent

NR 508 Week 7 Discussions 1 (Part Two) Recent

NR 508 Week 7 Discussions 1 (Part Two) Recent

discussion part two

your patient returns to your office 4 weeks following his initial appointment in part one with only moderate reduction in symptomology and an increase in nightly symptoms to 1 time per week. upon closer inspection of his medical records you notice that he has also been prescribed metoprolol (25 mg/day extended release) for uncontrolled familial hypertension.

what is the mechanism of action of metoprolol, and why is this an important issue in this patient? be sure to contrast the differences between your prescribed/discussed medication in parts one and the metoprolol just discovered. also, include your new patient plan with medication changes and details of dose and mechanism of action.


discussion part one 

elliot is a 74 year-old male who presents to your clinic with complaints of frequent nosebleeds (4 in the past week) and several severe bruises scattered variously throughout his anatomy. the patient is also complaining of a runny nose, cough, and head/chest congestion. he has a history of chronic atrial fibrillation and is currently prescribed and taking warfarin. approximately 3 weeks previously, he started taking over-the-counter cimetidine for heartburn he was experiencing.  below is a list of the patient’s medications, his physical examination, and his laboratory findings:


digoxin 0.25 mg qd cimetidine otc bid

pseudoephedrine sr 120 bid warfarin 7 mg qd

allergies: nkda 

physical examination

vs: bp: 180/95, hr 75, irregularly irregular, rr 17

weight: 95 kg

heent: wnl

abd: + bowel sounds ext: bruising on arms and legs

neuro: alert & oriented x 3 gen: well developed, well-nourished male

ecg: atrial fibrillation 


na 143 meq/l k 4.5 meq/l

cl 99 mmol/l co2 25 meq/l

bun 18 mg/dl scr 0.9 mg/dl

inr 4.8 hct 42%

hbg 15 mg/dl digoxin 3.8 ng/ml

what problems should be identified in this patient?

what are the precise mechanisms of action of each drug?

what do you think is contributing to the patient’s hypertension?

are there any drug interactions that you can identify as associated with this current drug regimen, and if so how, mechanistically, are they occurring?

what is the clinical significance of these interactions?